【研究發展處訊】
化學系江建緯助理教授發表最新期刊論文
Versatile Synthesis of Symmetric and Unsymmetric Imines via Photoelectrochemical Catalysis: Application to N-Terminal Modification of Phenylalanine
作者:Chien-Wei Chiang, Hung-Li Li, Ting-Jun Lin, Hung-Chi Chen, Yi-Hsien Chou, Chih-Ju Chou
Chemistry – A European Journal (SCI)
First published:11 July 2023
https://doi.org/10.1002/chem.202301379
摘要:
A strategy that combines electrochemical synthesis and photoredox catalysis was reported for the efficient synthesis of imines. This approach was demonstrated to be highly versatile in producing various types of imines, including symmetric and unsymmetric imines, by exploring the impact of different substituents on the benzene ring of the arylamine. Additionally, the method was specifically applied to modify N-terminal phenylalanine residues and was found to be successful in photoelectrochemical bioconjugation between NH2-Phe-OMe and aryl methylamines, leading to the synthesis of phenylalanine-containing imines. Therefore, this technique would present a convenient and efficient platform for synthesizing imines, with promising applications in chemical biology, drug development, and organic synthesis.
研究事務組提醒:教師如有最新發表於AHCI、SSCI、SCI、EI、TSSCI、THCI、「東吳大學外語學門獎勵名單」之期刊論文,歡迎將相關資訊e-mail至rad@scu.edu.tw,研究發展處將會公告於校園頭條,以廣交流。
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